Our client, a leading global pharmaceutical company, is looking for a skilled Functional Genomics Scientist IV to join their team in Fairfield County, CT!  This is a great opportunity to join a leading pharmaceutical company!

Location: Fairfield County, CT
Pay rate: $50/hr. - $53/hr.
Job type: 1 year contract

Position Summary
We are seeking a highly motivated Functional Genomics Scientist to design, develop, and execute advanced functional genomics assays. The successful candidate will have deep technical expertise in CRISPR-based genome editing, next-generation sequencing (NGS), and single-cell technologies. This role requires strong experimental design capabilities, hands-on laboratory experience, and the ability to interpret complex data while collaborating in a multidisciplinary research environment.

Key Responsibilities

• Design, develop, and execute functional genomics assays, including:
  • CRISPR-based editing (e.g., RNP delivery, knockout/knock-in strategies, Perturb-seq)
  • Single-cell sequencing technologies
  • Spatial transcriptomics
  • CITE-seq and related multi-omic platforms
• Personally design CRISPR guides, perform transfections/infections, select edited cells, and validate genome edits.
• Prepare next-generation sequencing libraries and conduct associated quality control procedures.
• Perform single-cell sample preparation, library generation, and QC assessments.
• Define and implement appropriate quality control measures across experiments.
• Troubleshoot technical challenges independently and collaboratively.
• Interpret experimental outcomes, propose follow-up studies, and contribute new investigative approaches.
• Maintain detailed and accurate laboratory records in compliance with established policies.
• Operate and maintain laboratory equipment in coordination with team members.
• Assist with procurement of laboratory supplies and equipment.

Required Qualifications

• Ph.D. or Master’s degree (with 6+ years of relevant experience) in Molecular Biology, Cell Biology, or a related scientific discipline.
• Hands-on experience designing and executing CRISPR assays, including guide design, delivery methods, selection, and validation of edited cells.
• Direct experience with NGS library preparation (not limited to data analysis).
• Practical experience with single-cell technologies, including sample preparation, library generation, and QC.
• Proficiency in standard molecular biology techniques such as qPCR, Western blotting, cloning, and gel electrophoresis.
• Strong cell culture skills, including maintenance of multiple cell lines and sterile technique.
• Ability to manage and perform multiple functional genomics experiments simultaneously.
• Demonstrated experience working in multidisciplinary, collaborative environments.
• Strong troubleshooting skills in functional genomics workflows.
• Experience with laboratory automation platforms and workflow optimization.

• Experience integrating multi-omic datasets.

*This job description is a complete list of all desired skills, but not all are required. We strongly encourage candidates who have some of the skills to apply. We look forward to a conversation to learn more about you! *


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